Exatecan mesylate is a drug that is used in the treatment of cancer. It belongs to a class of drugs called topoisomerase inhibitors, which work by inhibiting the activity of an enzyme called topoisomerase II. This enzyme is involved in the replication and repair of DNA, and by inhibiting its activity, exatecan mesylate can interfere with the growth and reproduction of cancer cells.
Exatecan mesylate
197720-53-9
C25H32FN3O9S
567.5838032
Description:
Exatecan mesylate is a novel anticancer agent that has been developed as a potential treatment for solid tumors and hematological malignancies. Exatecan mesylate is a prodrug of the active metabolite of exatecan, an anthracycline-based chemotherapy drug. The drug works by inhibiting topoisomerase II, an essential enzyme in DNA replication and repair.
Chemical Properties:
Pale Yellow to Yellow Solid
Uses:
Exatecan mesylate is specifically designed to target the epidermal growth factor receptor (EGFR) which is found on the surface of certain cancer cells. It binds to the EGFR and blocks its ability to activate certain proteins that help to stimulate the growth of cancer cells. By blocking the EGFR, Exatecan mesylate helps to stop the growth of the cancer cells and can even cause them to die.
One major benefit of Exatecan mesylate is its ability to target the EGFR without affecting normal cells. This is particularly important in the treatment of certain kinds of cancer, such as non-small cell lung cancer (NSCLC). In NSCLC, Exatecan mesylate has been shown to be more effective than other TKIs in stopping the growth of the cancer cells.
Chemical name: | Exatecan mesylate |
|---|---|
Cas No: | 197720-53-9 |
Molecular Formula: | C25H32FN3O9S |
Formula Weight: | 567.5838032 |
Apperance: | Pale Yellow to Yellow Solid |
Purity: | 99% |
Storage conditions： | Hygroscopic, Refrigerator, Under inert atmosphere |
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Tags: Exatecanmesilatehydrate; Exatecanmesilatehydrate(JAN); Exatecanmesylate; Exatecanmesylate(USAN); Exatecanmesylatehydrate; (1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-mChemicalbookethyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione,mesylate; Exatecanmesylatedihydrate; Exatecanmesilate,DX-8951f
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