Hexadecanoic acid, 16-bromo-, 1,1-dimethylethyl ester

Targeted Protein Degradation (PROTAC Linkers): Acts as an optimal 16-carbon aliphatic linker to bridge target protein ligands and E3 ligase ligands, enabling efficient cell-permeable PROTAC synthesis.
LNP & Nucleic Acid Delivery (mRNA/siRNA): Serves as a critical precursor for synthesizing novel ionizable lipids and cationic lipids, facilitating stable Lipid Nanoparticle (LNP) formulation and high-efficiency intracellular delivery
Peptide Lipidation (Half-life Extension): Utilized in the structural modification of therapeutic peptides (e.g., GLP-1 analogs) to promote albumin binding and significantly extend in vivo half-life.
Advanced Organic Synthesis: A highly versatile “building block” allowing selective nucleophilic substitution at the bromine terminal followed by controlled acidic deprotection of the carboxyl group.