Opicapone

Opicapone is a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase. It has a molecular formula of C15H10Cl2N4O6 and is used as a biochemical for proteomics research. Opicapone decreases the ATP content and mitochondrial membrane potential in cells, with IC50 values of 98 μM and 181 μM respectively. It is also administered with L-DOPA to treat Parkinson's disease.

923287-50-7

Chemical Name:

Opicapone

CAS No:

923287-50-7

Molecular Fomula:

C15H10Cl2N4O6

Formula Weight:

413.17

Chemical Uses

Description:

Opicapone is an innovative, long-acting, peripherally selective inhibitor of catechol-O-methyltransferase (COMT), with a molecular formula of C15H10Cl2N4O6. It is used as a biochemical tool for proteomics research and has been found to decrease the ATP content and mitochondrial membrane potential in cells, with IC50 values of 98 μM and 181 μM respectively.

Uses:

Opicapone has more to offer than just proteomics research. It is also administered with L-DOPA to treat Parkinson’s disease, as it can help reduce the amount of L-DOPA needed to achieve symptomatic relief. This means that it can also help improve the symptoms of Parkinson’s disease, such as shaking and difficulty with movement. 

In addition, Opicapone has been found to help improve the symptoms of restless leg syndrome, another condition that affects people with Parkinson’s disease. It works by decreasing the amount of dopamine, the neurotransmitter responsible for movement and alertness. This can help people with Parkinson’s disease and restless leg syndrome to relax and move more easily.

Chemical Properties

Chemical name:

Opicapone

Cas No:

923287-50-7

Molecular Formula:

C15H10Cl2N4O6

Formula Weight:

413.17 g/mol

Boiling point

701.1±70.0 °C(Predicted)

Density

1.389

pka

4.67±0.38(Predicted)

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